De-Risking Clinical Trials: Gain in-depth Understanding of your Drug

The step from drug discovery to clinical development is one of the most challenging hurdles, but also one of the most value gaining transformation of a potential drug. The most promising approach is to gain an in-depth  understanding of your molecule as well as of the patient population which most likely benefits from treatment. This strategy enables a smart design of a clinical development campaign and contributes to increasing your chances of success.

In this virtual conference representatives from research organizations, Big pharma and CRO industry presented in-depth compound characterizations covering:

  • Target deconvolution
  • Mode of action characterization
  • Biomarker identification
  • Drug repurposing
  • In-depth DMPK and PK-PD understanding
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Introduction

With Dr. Charlotte Kopitz

Head of Therapeutic Research at NUVISAN ICB GmbH

Day 1 - December 1, 2021

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Pharmacological characterization of antibody-drug-conjugates (ADCs)

With Dr. Sven Christophe Golfier

Principal Scientist, Translational Research at NUVISAN ICB GmbH

Day 1 - December 1, 2021

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Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer

With Dr. Sebastian Dieter

Physician Scientist at National Center for Tumor Diseases (NCT) Heidelberg/ German Cancer Research Center (DKFZ) Heidelberg

Day 1 - December 1, 2021

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PDE3A-SLFN12 complex formation for cancer therapy

With Heidi Greulich

Senior group leader at The Broad Institute of MIT and Harvard

Day 1 - December 1, 2021

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Chemical probes as a validation tool to de-risk drug discovery & development: Exploring MENIN-MLL interaction as therapeutic target

With Dr. Carlo Stresemann

Head of Therapeutic Oncology Research at NUVISAN ICB GmbH

Day 1 - December 1, 2021

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Conclusion

With Dr. Charlotte Kopitz

Head of Therapeutic Research at NUVISAN ICB GmbH

Day 1 - December 1, 2021

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Introduction

With Dr. Olaf Prien

Head of Preclinical Compound Profiling at NUVISAN ICB GmbH

Day 1 - December 2, 2021

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Transforming PK/PD Modeling into the New Era of Drug Discovery

With Dr. Andreas Reichel

VP - Head DMPK Modelling and Simulation at BAYER AG

Day 1 - December 2, 2021

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Model-informed drug development in Oncology

With Dr. Spyros Stamatelo

Senior Director Clinical Pharmacology / Oncology at BAYER AG

Day 1 - December 2, 2021

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Preclinical PK experiments to support mechanistic understanding of clinical observations – a project example

With Dr. Christian Zurth

Senior Pharmacokinetics Expert at BAYER AG

Day 1 - December 2, 2021

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MALDI-MS

With Dr. Michael Niehues

Head of Structure & Sample Analytic at NUVISAN ICB GmbH

Day 1 - December 2, 2021

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Conclusion

With Dr. Olaf Prien

Head of Preclinical Compound Profiling at NUVISAN ICB GmbH

Day 1 - December 2, 2021