How to improve drug tolerance in competitive ligand binding NAb assays

With Dr. Regina Bruyns & Dr. Sripriya Jaganathan

Administration of large molecules can trigger an immune response in patients, leading to the production of anti-drug-antibodies (ADA). Neutralizing antibodies (NAb) are a specific type of ADA that reduce the therapeutic effect by interfering with the drug-target interaction, thereby neutralizing drug’s efficacy, and causing unwanted adverse effects. Thus, it is crucial to detect the levels of NAb in serum of patients.